[18F]-FDG PET-CT prediction of response to induction chemotherapy in head and neck squamous cell carcinoma: Preliminary findings - 17/02/15
, N. Prevot-Bitot c, A. Timoschenko a, P. Gallet d, C. Martin a, J.-M. Prades a, bBienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Objectives |
The present study assessed the predictive value of [18F]-FDG PET-CT (positron emission tomography with 18-fluoro-eoxyglucose radiotracer, coupled to computerized tomography) for response to induction chemotherapy in head and neck squamous cell carcinoma (HNSCC).
Material and methods |
[18F]-FDG PET-CT was systematically performed before treatment initiation and after the first cycle of chemotherapy. Results were compared with those of endoscopy and pathologic analysis of biopsy and surgical specimens.
Results |
This preliminary study included 21 previously untreated HNSCC patients. A decrease of more than 30% in SUVmax (maximum standard uptake value) during induction was predictive of tumor response to chemotherapy (P=0.04). PET-CT measurement of hypermetabolic volume based on a predetermined SUV threshold (SUV=2.5), on the other hand, proved non-predictive.
Conclusion |
These preliminary findings are promising. A larger sample, however, would be required in order to determine a more precise SUVmax reduction cut-off threshold during induction. Other methods for determining metabolic volume thresholds will be investigated. If functional imaging proves contributive, it could enable early screening of non-responders, avoiding unnecessary intoxication.
Le texte complet de cet article est disponible en PDF.Keywords : PET-CT, 18-fluorodeoxyglucose, Head and neck squamous cell carcinoma, TPF induction chemotherapy
Plan
Vol 132 - N° 1
P. 3-7 - février 2015 Retour au numéro
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